Epithelial–mesenchymal transition (EMT) is crucial in embryogenesis and can be exploited by cancer cells to gain metastatic abilities. A hallmark of EMT is E-cadherin loss. In 2000, Snail was reported as the first E-cadherin repressor identified in the context of EMT, advancing our understanding of embryonic development and cancer progression.
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Sun, Y., Ma, L. A milestone in epithelial–mesenchymal transition. Nat Cell Biol 26, 29–30 (2024). https://doi.org/10.1038/s41556-023-01228-3
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DOI: https://doi.org/10.1038/s41556-023-01228-3
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