Skip to main content
SpringerLink
Log in

Development

Pausing pluripotency via RNA methylation

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

Embryonic diapause in development and paused pluripotency in embryonic stem cells result in a state of hypotranscription through mechanisms that remain unclear. A new study dissects the role of METTL3-deposited global m6A RNA methylation in mediating this transcriptional dormancy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: m6A modification of mRNA mediates hypotranscription during embryonic diapause.

References

  1. Renfree, M. B. & Fenelon, J. C. Development 144, 3199–3210 (2017).

    Article  CAS  PubMed  Google Scholar 

  2. Bulut-Karslioglu, A. et al. Nature 540, 119–123 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Xu, X. et al. EMBO Rep. 23, e53081 (2022).

    Article  CAS  PubMed  Google Scholar 

  4. Collignon, E. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01212-x (2023).

  5. He, P. C. & He, C. EMBO J. 40, e105977 (2021).

  6. Murakami, S. & Jaffrey, S. R. Mol. Cell 82, 2236–2251 (2022).

  7. Liu, G. Y. & Sabatini, D. M. Nat. Rev. Mol. Cell Biol. 21, 183–203 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Cho, S. et al. Mol. Cell 81, 2064–2075 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Villa, E. et al. Mol. Cell 81, 2076–2093 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Tang, H. W. et al. Proc. Natl. Acad. Sci. USA 118, e2021945118 (2021).

Download references

Author information

Authors and Affiliations

  1. Laboratory of Metabolism and Cell Fate, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

    Xueting Xu & Baoming Qin

Authors
  1. Xueting Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Baoming Qin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Baoming Qin.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xu, X., Qin, B. Pausing pluripotency via RNA methylation. Nat Cell Biol 25, 1241–1242 (2023). https://doi.org/10.1038/s41556-023-01203-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-023-01203-y

  • Springer Nature Limited

Search

Navigation