Sphingomyelin synthase 2 foci assemble at the leading edge of the basal membrane in migrating cells, and these foci eventually become sites of migrasome formation. Conversion of ceramide to sphingomyelin spurs migrasome growth and preserves the structural integrity of these organelles.
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References
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This is a summary of: Liang, H. et al. The formation of migrasomes is initiated by the assembly of sphingomyelin synthase 2 foci at the leading edge of migrating cells. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01188-8 (2023).
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Sphingomyelin synthase 2 foci determine sites of migrasome formation. Nat Cell Biol 25, 1087–1088 (2023). https://doi.org/10.1038/s41556-023-01199-5
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DOI: https://doi.org/10.1038/s41556-023-01199-5
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