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DMRT1 drives the human germline forward

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The molecular program of human germline commitment remains largely unknown. A new study delineates the multifaceted functions of DMRT1 in human germline development, particularly in the transition from early to late primordial germ cells.

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Fig. 1: Schematic diagram of the molecular regulatory network of human germline development and the extensive role of DMRT1.

References

  1. Li, L. et al. Cell Stem Cell 20, 858–873 (2017).

    Article  CAS  PubMed  Google Scholar 

  2. Tang, W. W. et al. Cell 161, 1453–1467 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Tang, W. W., Kobayashi, T., Irie, N., Dietmann, S. & Surani, M. A. Nat. Rev. Genet. 17, 585–600 (2016).

    Article  CAS  PubMed  Google Scholar 

  4. Irie, N. et al. Cell 160, 253–268 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Kojima, Y. et al. Cell Stem Cell 21, 517–532 (2017).

    Article  CAS  PubMed  Google Scholar 

  6. Chen, D. et al. Cell Rep. 25, 3591–3602 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Chen, D. et al. Cell Rep. 29, 4568–4582 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Sybirna, A. et al. Nat. Commun. 11, 1282 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Zarkower, D. Curr. Topics Dev. Biol. 102, 327–356 (2013).

    Article  CAS  Google Scholar 

  10. Jorgensen, A., Nielsen, J. E., Blomberg Jensen, M., Graem, N. & Rajpert-De Meyts, E. Mol. Hum. Reprod. 18, 523–534 (2012).

    Article  CAS  PubMed  Google Scholar 

  11. Irie, N. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01224-7 (2023).

    Article  PubMed  Google Scholar 

  12. Jung, D. et al. Nat. Commun. 8, 15680 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Zhang, T. & Zarkower, D. Stem Cell Res. 24, 195–202 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Guo, J. et al. Cell Stem Cell 28, 764–778 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Kee, K., Angeles, V. T., Flores, M., Nguyen, H. N. & Reijo Pera, R. A. Nature 462, 222–225 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Jie Qiao.

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Lu, Y., Yuan, P. & Qiao, J. DMRT1 drives the human germline forward. Nat Cell Biol 25, 1408–1410 (2023). https://doi.org/10.1038/s41556-023-01196-8

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