RNA modifications have emerged as key gene regulators. A new study shows that increased levels of reactive oxygen species in cancer induce widespread, sequence-specific modifications of guanines in the seed regions of microRNAs, altering the targets of those miRNAs and influencing tumorigenesis.
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18 September 2023
A Correction to this paper has been published: https://doi.org/10.1038/s41556-023-01256-z
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Montes, M., Huarte, M. o8G modifications rewire tumoral microRNAs. Nat Cell Biol 25, 1243–1244 (2023). https://doi.org/10.1038/s41556-023-01179-9
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DOI: https://doi.org/10.1038/s41556-023-01179-9
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