Receptor-mediated endocytosis delivers low-density lipoproteins (LDLs) to late endosomes, from where cholesterol is trafficked to mitochondria. Zhou et al. report that LDL-containing endosomes fuse with mitochondria, supplying cholesterol for steroid biosynthesis and enabling mitochondrial degradation of the LDL receptor.
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Shinjo, S., Scorrano, L. LDLs take a shortcut to mitochondria. Nat Cell Biol 25, 919–920 (2023). https://doi.org/10.1038/s41556-023-01166-0
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DOI: https://doi.org/10.1038/s41556-023-01166-0
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