The house-keeping aminoacyl-tRNA synthetases are increasingly recognized for their regulatory roles beyond protein synthesis. Research now uncovers a function of nuclear arginyl-tRNA synthetase in the regulation of alternative mRNA splicing through SRRM2 in response to inflammation and decreased arginine levels.
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Chen, J. Arginyl-tRNA synthetase in inflammation. Nat Cell Biol 25, 520–521 (2023). https://doi.org/10.1038/s41556-023-01090-3
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DOI: https://doi.org/10.1038/s41556-023-01090-3
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