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Extracellular vesicles

Niche tension controls exosome production

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Extracellular matrix (ECM) stiffening is a hallmark of cancer aggressiveness. Diverse ECM environments can alter the number and cargo of small extracellular vesicles (sEVs). Wu et al. now delineate a pathway from ECM stiffness to FAK/PI3K/Akt signalling and Rab8-induced sEV secretion, promoting cancer growth.

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Fig. 1: ECM stiffening activates a FAK/PI3K/Akt signalling pathway to activate Rab8-mediated exosome secretion.

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Authors and Affiliations

  1. Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA

    Toni Renee Dawson & Alissa Margaret Weaver

  2. Center for Extracellular Vesicle Research, Vanderbilt University School of Medicine, Nashville, TN, USA

    Toni Renee Dawson & Alissa Margaret Weaver

  3. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA

    Alissa Margaret Weaver

Authors
  1. Toni Renee Dawson
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  2. Alissa Margaret Weaver
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Correspondence to Alissa Margaret Weaver.

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The authors declare no competing interests.

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Dawson, T.R., Weaver, A.M. Niche tension controls exosome production. Nat Cell Biol 25, 377–378 (2023). https://doi.org/10.1038/s41556-023-01088-x

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