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Stem cells

A seed-and-soil theory for blood ageing

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The bone marrow is the daily production site for hundreds of billions of blood cells. A new study adds evidence that, during ageing, signals emanating from bone-marrow stromal cells shift to produce inflammatory factors that skew blood-cell output, driving age-related tissue deterioration.

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Fig. 1: Ageing of the stromal niche in the bone marrow affects the output of blood stem cells.

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Author notes

  1. The authors contributed equally: Thomas H. Ambrosi, Charles K. F. Chan.

Authors and Affiliations

  1. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA

    Thomas H. Ambrosi & Charles K. F. Chan

  2. Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA

    Thomas H. Ambrosi & Charles K. F. Chan

Authors
  1. Thomas H. Ambrosi
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  2. Charles K. F. Chan
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Correspondence to Charles K. F. Chan.

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The authors declare no competing interests.

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Ambrosi, T.H., Chan, C.K.F. A seed-and-soil theory for blood ageing. Nat Cell Biol 25, 9–11 (2023). https://doi.org/10.1038/s41556-022-01062-z

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