FG-nucleoporins of the nuclear pore complexes form a permeability barrier between the nucleus and the cytosol. FG-nucleoporins contain disordered regions and are prone to aggregation. Two studies identify the chaperone DNAJB6 as a key factor that prevents aggregation of FG-nucleoporins and assists in the biogenesis of nuclear pore complexes.
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Kirstein, J. Chaperoning the nuclear envelope. Nat Cell Biol 24, 1563–1564 (2022). https://doi.org/10.1038/s41556-022-01013-8
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DOI: https://doi.org/10.1038/s41556-022-01013-8
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