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Opportunities and challenges in studying the extracellular vesicle corona

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The extracellular vesicle (EV) surface corona is emerging as a crucial mediator of EV functions. This Comment discusses the roles and biogenesis of the EV corona, as well as the importance of controls to determine whether a biological effect is attributable to the internal EV cargo or to the corona associated with the EV exofacial surface.

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Fig. 1: Formation of a biomolecular corona around EVs.

References

  1. Théry, C. et al. J. Extracell. Vesicles 7, 1535750 (2018).

    Article  Google Scholar 

  2. Tóth, E. Á. et al. J. Extracell. Vesicles 10, e12140 (2021).

    Article  Google Scholar 

  3. Palviainen, M. et al. PLoS One 15, e0236439 (2020).

    Article  CAS  Google Scholar 

  4. Yerneni, S. S., Solomon, T., Smith, J. & Campbell, P. G. Biochim. Biophys. Acta Gen. Subj. 1866, 130069 (2022).

    Article  CAS  Google Scholar 

  5. Wolf, M. et al. J. Extracell. Vesicles 11, e12207 (2022).

    Article  CAS  Google Scholar 

  6. Sung, B. H. et al. Nat. Commun. 6, 7164 (2015).

    Article  CAS  Google Scholar 

  7. Varga, Z. et al. Colloids Surf. B Biointerfaces 192, 111053 (2020).

    Article  CAS  Google Scholar 

  8. Santucci, L. et al. Sci. Rep. 9, 13048 (2019).

    Article  CAS  Google Scholar 

  9. Buzás, E. I., Tóth, E. Á., Sódar, B. W. & Szabó-Taylor, K. É. Semin. Immunopathol. 40, 453–464 (2018).

    Article  Google Scholar 

  10. Meneghetti, M. C. et al. J. R. Soc. Interface. 12, 0589 (2015).

    Article  Google Scholar 

  11. Toledo, A. G. et al. J. Histochem. Cytochem. 69, 105–119 (2021).

    Article  Google Scholar 

  12. Baglio, S. R. et al. Clin. Cancer Res. 23, 3721–3733 (2017).

    Article  CAS  Google Scholar 

  13. Genschmer, K. R. et al. Cell 176, 113–126.e15 (2019).

    Article  CAS  Google Scholar 

  14. Németh, A. et al. Sci. Rep. 7, 8202 (2017).

    Article  Google Scholar 

  15. Lázaro-Ibáñez, E. et al. J. Extracell. Vesicles 8, 1656993 (2019).

    Article  Google Scholar 

  16. Michell, D. L. & Vickers, K. C. Biochim. Biophys Acta 1861, 2069–2074 (2016).

    Article  CAS  Google Scholar 

  17. van Niel, G. et al. Cell Rep. 13, 43–51 (2015).

    Article  Google Scholar 

  18. Solvik, T. A. et al. J. Cell Biol. 221, e202110151 (2022).

    Article  Google Scholar 

  19. Welton, J. L. et al. J. Extracell. Vesicles 6, 1369805 (2017).

    Article  Google Scholar 

  20. Papini, E., Tavano, R. & Mancin, F. Front. Immunol. 11, 567365 (2020).

    Article  CAS  Google Scholar 

  21. Willis, C. M. et al. Proc. Natl Acad. Sci. USA 116, 10488–10493 (2019).

    Article  CAS  Google Scholar 

  22. Busatto, S. et al. J. Nanobiotechnology 18, 162 (2020).

    Article  CAS  Google Scholar 

  23. Luga, V. et al. Cell 151, 1542–1556 (2012).

    Article  CAS  Google Scholar 

  24. Ugalde, C. L. et al. J. Extracell. Vesicles 10, e12034 (2020).

    Article  CAS  Google Scholar 

  25. Wu, J. Y. et al. J. Nanobiotechnology 19, 405 (2021).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary

    Edit I. Buzas

  2. HCEMM-SU Extracellular Vesicles Research Group, Budapest, Hungary

    Edit I. Buzas

  3. ELKH-SE Translational Extracellular Vesicles Research Group, Budapest, Hungary

    Edit I. Buzas

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  1. Edit I. Buzas
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Correspondence to Edit I. Buzas.

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Competing interests

The author is a member of the advisory board of Sphere Gene Therapeutics Inc. (Boston, USA).

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Buzas, E.I. Opportunities and challenges in studying the extracellular vesicle corona. Nat Cell Biol 24, 1322–1325 (2022). https://doi.org/10.1038/s41556-022-00983-z

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