Skip to main content
SpringerLink
Log in

EPIGENETICS

Don’t put all your epigenetic eggs in one basket

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

In Caenorhabditis elegans, RNAi-initiated gene silencing can persist for multiple generations. A study shows that this heritable silencing requires parallel contributions of both a nuclear transcriptional silencing pathway and perinuclear condensate-localized poly(UG)-tailed transcripts to produce abundant germline siRNAs in adult progeny.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Complementary HRDE-1- and ZNFX-1-dependent heritable RNAi.

References

  1. Watson, J. D. & Crick, F. H. Nature 171, 964–967 (1953).

    Article  CAS  Google Scholar 

  2. Meselson, M. & Stahl, F. W. Proc. Natl Acad. Sci. USA 44, 671–682 (1958).

    Article  CAS  Google Scholar 

  3. Fire, A. et al. Nature 391, 806–811 (1998).

    Article  CAS  Google Scholar 

  4. Buckley, B. A. et al. Nature 489, 447–451 (2012).

    Article  CAS  Google Scholar 

  5. Alcazar, R. M., Lin, R. & Fire, A. Z. Genetics 180, 1275–1288 (2008).

    Article  CAS  Google Scholar 

  6. Ouyang, J. P. T., Zhang, W. L. & Seydoux, G. Nat. Cell Biol. https://doi.org/10.1038/s41556-022-00940-w (2022).

    Article  PubMed  Google Scholar 

  7. Shukla, A. et al. Nature 582, 283–288 (2020).

    Article  CAS  Google Scholar 

  8. Yigit, E. et al. Cell 127, 747–757 (2006).

    Article  CAS  Google Scholar 

  9. Sapetschnig, A., Sarkies, P., Lehrbach, N. J. & Miska, E. A. PLoS Genet. 11, e1005078 (2015).

    Article  Google Scholar 

  10. Ishidate, T. et al. Mol. Cell 70, 639–649.E6 (2018).

    Article  CAS  Google Scholar 

  11. Wan, G. et al. Nature 557, 679–683 (2018).

    Article  CAS  Google Scholar 

  12. Shukla, A., Perales, R. & Kennedy, S. Curr. Biol. 31, 4473–4485.e3 (2021).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Biological Laboratories, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA

    Nicole M. Bush & Craig P. Hunter

Authors
  1. Nicole M. Bush
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Craig P. Hunter
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Craig P. Hunter.

Ethics declarations

Competing interests

N.M.B. and C.P.H. declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bush, N.M., Hunter, C.P. Don’t put all your epigenetic eggs in one basket. Nat Cell Biol 24, 1016–1018 (2022). https://doi.org/10.1038/s41556-022-00948-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-022-00948-2

  • Springer Nature Limited

Search

Navigation