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NUCLEAR TRANSPORT

Forced entry into the nucleus

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The nuclear pore complex (NPC) regulates transport of macromolecules into and out of the nucleus. A study now shows that mechanical force applied on the nucleus affects the transport rates across the NPC diffusion barrier, modulating the nuclear localization of certain cargos.

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Fig. 1: Mechanical tuning of nucleocytoplasmic transport.

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Authors and Affiliations

  1. California Institute of Technology, Division of Chemistry and Chemical Engineering, Pasadena, CA, USA

    Stefan Petrovic & André Hoelz

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  1. Stefan Petrovic
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  2. André Hoelz
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Correspondence to André Hoelz.

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The authors declare no competing interests.

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Petrovic, S., Hoelz, A. Forced entry into the nucleus. Nat Cell Biol 24, 810–812 (2022). https://doi.org/10.1038/s41556-022-00939-3

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