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CELL CYCLE

Defining cancer growth beyond the mitotic index

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Tumour growth involves anomalies in cell cycle genes and emergent phenotypes, but the tumour proliferation rate (or mitotic index) is defined by just one marker, Ki-67. A study now integrates expression patterns of several markers to generate spatio-temporal maps of cell proliferation in cancer tissues.

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Fig. 1: Development of a multivariate proliferation metric, and spatio-temporal mapping of cell proliferation landscape in tumour samples.

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Authors and Affiliations

  1. Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA

    Chandan Kumar-Sinha & Arul M. Chinnaiyan

  2. Department of Pathology, University of Michigan, Ann Arbor, MI, USA

    Chandan Kumar-Sinha & Arul M. Chinnaiyan

  3. Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA

    Arul M. Chinnaiyan

  4. Howard Hughes Medical Institute, Chevy Chase, MD, USA

    Arul M. Chinnaiyan

Authors
  1. Chandan Kumar-Sinha
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  2. Arul M. Chinnaiyan
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Correspondence to Arul M. Chinnaiyan.

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The authors declare no competing interests.

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Kumar-Sinha, C., Chinnaiyan, A.M. Defining cancer growth beyond the mitotic index. Nat Cell Biol 24, 285–287 (2022). https://doi.org/10.1038/s41556-022-00862-7

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