The integrity of the mitochondrial genome (mitochondrial DNA) is crucial for energy synthesis in all complex life. A study now reveals a vicious cycle of mtDNA replication within dysfunctional mitochondria that preferentially propagates genomes carrying deleterious mutations.
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Kirmes, I., Zuryn, S. LONP-1 aids propagation of deleterious mtDNA. Nat Cell Biol 24, 127–128 (2022). https://doi.org/10.1038/s41556-021-00838-z
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DOI: https://doi.org/10.1038/s41556-021-00838-z
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