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NUCLEAR TRANSPORT

Mapping paths through the nuclear pore complex

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An Author Correction to this article was published on 08 February 2022

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Nuclear pore complexes (NPCs) facilitate the fast, yet highly selective, nucleocytoplasmic transport of molecules. A recent study describes a multicolour imaging approach to chart the paths for cargo molecules through the human NPC with real-time 3D visualization of nucleocytoplasmic transport events with high spatial and temporal precision.

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Fig. 1: NTRs distribution within the NPC.

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References

  1. Lin, D. H. & Hoelz, A. Annu. Rev. Biochem. 88, 725–783 (2019).

    Article  CAS  Google Scholar 

  2. Hampoelz, B. et al. Annu. Rev. Biophys. 48, 515–536 (2019).

    Article  CAS  Google Scholar 

  3. Fernandez-Martinez, J. & Rout, M. P. Trends Biochem. Sci. 46, 595–607 (2021).

    Article  CAS  Google Scholar 

  4. Chowdhury, R., Sau, A. & Musser, S. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00815-6 (2021).

  5. Dickmanns, A., Kehlenbach, R. H. & Fahrenkrog, B. Int. Rev. Cell Mol. Biol. 320, 171–233 (2015).

    Article  CAS  Google Scholar 

  6. Coyne, A. N. et al. Neuron 107, 1124–1140 (2020).

    Article  CAS  Google Scholar 

  7. Paine, P. L., Moore, L. C. & Horowitz, S. B. Nature 254, 109114 (1975).

    Article  Google Scholar 

  8. Ribbeck, K. & Gorlich, D. EMBO J. 20, 1320–1330 (2001).

    Article  CAS  Google Scholar 

  9. Schuller, A. P. et al. Nature 598, 667–671 (2021).

    Article  CAS  Google Scholar 

  10. Kapinos, L. E. et al. J. Cell Biol. 216, 3609–3624 (2017).

    Article  CAS  Google Scholar 

  11. Zimmerli, C. E. et al. Science https://doi.org/10.1126/science.abd9776 (2021).

  12. Mackmull, M. T. et al. Mol. Syst. Biol. 13, 962 (2017).

    Article  Google Scholar 

  13. Paci, G., Caria, J. & Lemke, E. A. J. Cell Sci. 134, jcs247874 (2021).

    Article  CAS  Google Scholar 

  14. Dasso, M. Curr. Biol. 12, R502–R508 (2002).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Figure 1 was created using BioRender and Microsoft PowerPoint software.

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Correspondence to Vasilisa Aksenova.

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Aksenova, V., Dasso, M. Mapping paths through the nuclear pore complex. Nat Cell Biol 24, 6–7 (2022). https://doi.org/10.1038/s41556-021-00823-6

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