Nuclear pore complexes (NPCs) facilitate the fast, yet highly selective, nucleocytoplasmic transport of molecules. A recent study describes a multicolour imaging approach to chart the paths for cargo molecules through the human NPC with real-time 3D visualization of nucleocytoplasmic transport events with high spatial and temporal precision.
Change history
08 February 2022
A Correction to this paper has been published: https://doi.org/10.1038/s41556-022-00859-2
References
Lin, D. H. & Hoelz, A. Annu. Rev. Biochem. 88, 725–783 (2019).
Hampoelz, B. et al. Annu. Rev. Biophys. 48, 515–536 (2019).
Fernandez-Martinez, J. & Rout, M. P. Trends Biochem. Sci. 46, 595–607 (2021).
Chowdhury, R., Sau, A. & Musser, S. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00815-6 (2021).
Dickmanns, A., Kehlenbach, R. H. & Fahrenkrog, B. Int. Rev. Cell Mol. Biol. 320, 171–233 (2015).
Coyne, A. N. et al. Neuron 107, 1124–1140 (2020).
Paine, P. L., Moore, L. C. & Horowitz, S. B. Nature 254, 109114 (1975).
Ribbeck, K. & Gorlich, D. EMBO J. 20, 1320–1330 (2001).
Schuller, A. P. et al. Nature 598, 667–671 (2021).
Kapinos, L. E. et al. J. Cell Biol. 216, 3609–3624 (2017).
Zimmerli, C. E. et al. Science https://doi.org/10.1126/science.abd9776 (2021).
Mackmull, M. T. et al. Mol. Syst. Biol. 13, 962 (2017).
Paci, G., Caria, J. & Lemke, E. A. J. Cell Sci. 134, jcs247874 (2021).
Dasso, M. Curr. Biol. 12, R502–R508 (2002).
Acknowledgements
Figure 1 was created using BioRender and Microsoft PowerPoint software.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Aksenova, V., Dasso, M. Mapping paths through the nuclear pore complex. Nat Cell Biol 24, 6–7 (2022). https://doi.org/10.1038/s41556-021-00823-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-021-00823-6
- Springer Nature Limited