How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.
References
Lohela, M. et al. Curr. Opin. Cell Biol. 21, 154–165 (2009).
Koltowska, K. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00784-w (2021).
Hogan, B. M. & Schulte-Merker, S. Dev. Cell 42, 567–583 (2017).
Bianchi, R. et al. Arterioscler. Thromb. Vasc. Biol. 37, 108–117 (2017).
Mendola, A. et al. Mol. Syndromol. 4, 257–266 (2013).
Calo, E. et al. Nature 518, 249–253 (2015).
Song, C. et al. Genes Dev. 31, 1370–1381 (2017).
Lee, H.-W., Yu, P. & Simons, M. F1000Res. 7, 1114 (2018).
Pontes-Quero, S. et al. Nat. Commun. 10, 2016 (2019).
Jerafi-Vider, A. et al. Cell Rep. 35, 109255 (2021).
Kang, J. et al. Sig. Transduct. Target. Ther. 6, 323 (2021).
Macias, E. et al. Cancer Cell 18, 231–243 (2010).
Van Riggelen, J., Yetil, A. & Felsher, D. W. Nat. Rev. Cancer 10, 301–309 (2010).
Kampen, K. R. et al. Nucleic Acids Res. 48, 1013–1028 (2020).
Calo, E. et al. Nature 554, 112–117 (2018).
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Mühleder, S., Benedito, R. An RNA helicase swirls in lymphangiogenesis. Nat Cell Biol 23, 1109–1110 (2021). https://doi.org/10.1038/s41556-021-00789-5
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DOI: https://doi.org/10.1038/s41556-021-00789-5
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