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DNA REPAIR

ASTE1 cutting to block DNA end resection

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Cells rely on two main pathways to repair DNA lesions, homologous recombination and non-homologous end-joining, and how they decide to use one machinery over the other is not clear. A recent study identifies ASTE1 as a regulator controlling pathway choice.

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Fig. 1: Role of ASTE1 in DNA repair.

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Authors and Affiliations

  1. Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

    Yizhou Joseph He & Dipanjan Chowdhury

  2. Broad Institute of Harvard and MIT, Cambridge, MA, USA

    Dipanjan Chowdhury

  3. Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA

    Dipanjan Chowdhury

Authors
  1. Yizhou Joseph He
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  2. Dipanjan Chowdhury
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Correspondence to Dipanjan Chowdhury.

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The authors declare no competing interests.

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He, Y.J., Chowdhury, D. ASTE1 cutting to block DNA end resection. Nat Cell Biol 23, 818–819 (2021). https://doi.org/10.1038/s41556-021-00731-9

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