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LIS1 cracks open dynein

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Active transport along microtubules by molecular motors is a crucial cellular process that is disrupted in human diseases. Single-molecule studies from three independent groups reveal a new molecular mechanism for how cells control the activity of the complex microtubule motor cytoplasmic dynein via the neurodevelopmental protein LIS1.

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Fig. 1: Model for LIS1 function in the assembly of activated dynein–dynactin–cargo-adapter complexes.

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Authors and Affiliations

  1. Department of Molecular and Cellular Biology, University of California – Davis, Davis, CA, USA

    Richard J. McKenney

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  1. Richard J. McKenney
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Correspondence to Richard J. McKenney.

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McKenney, R.J. LIS1 cracks open dynein. Nat Cell Biol 22, 515–517 (2020). https://doi.org/10.1038/s41556-020-0500-5

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