Misfolded proteins in the endoplasmic reticulum (ER) are returned to the cytosol and destroyed by a process known as ER-associated degradation (ERAD). Hrd1 has been implicated as the channel that mediates the transport of ERAD substrates to the cytosol. A study demonstrates that Hrd1 is gated by autoubiquitination and a soluble ERAD substrate.
This is a preview of subscription content, log in via an institution to check access.
References
Brodsky, J. L. Cell 151, 1163–1167 (2012).
Carvalho, P., Stanley, A. M. & Rapoport, T. A. Cell 143, 579–591 (2010).
Stein, A., Ruggiano, A., Carvalho, P. & Rapoport, T. A. Cell 158, 1375–1388 (2014).
Baldridge, R. D. & Rapoport, T. A. Cell 166, 394–407 (2016).
Schoebel, S. et al. Nature 548, 352–355 (2017).
Vasic, V. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-020-0473-4 (2020).
Hampton, R. Y., Gardner, R. G. & Rine, J. Mol. Biol. Cell 7, 2029–2044 (1996).
Knop, M., Finger, A., Braun, T., Hellmuth, K. & Wolf, D. H. EMBO J. 15, 753–763 (1996).
Carvalho, P., Goder, V. & Rapoport, T. A. Cell 126, 361–373 (2006).
Denic, V., Quan, E. M. & Weissman, J. S. Cell 126, 349–359 (2006).
Meinecke, M. et al. Nat. Cell Biol. 12, 273–277 (2010).
Wirth, A. et al. Mol. Cell 12, 261–268 (2003).
Mehnert, M. et al. Mol. Biol. Cell 26, 185–194 (2015).
Sato, B. K., Schulz, D., Do, P. H. & Hampton, R. Y. Mol. Cell 34, 212–222 (2009).
Ravid, T., Kreft, S. G. & Hochstrasser, M. EMBO J. 25, 533–543 (2006).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Betegon, M., Brodsky, J.L. Unlocking the door for ERAD. Nat Cell Biol 22, 263–265 (2020). https://doi.org/10.1038/s41556-020-0476-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-020-0476-1
- Springer Nature Limited