Skip to main content
SpringerLink
Log in

MEMBRANE TRAFFICKING

L(C3)icensing of exosomes for RNA export

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

A mechanism of secretory autophagy explains aspects of the packaging of proteins and RNA into extracellular vesicles and paves the way to a better understanding of their biological roles and medical applications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: LDELS: autophagy-dependent packaging and exosomal secretion mechanism of cellular proteins and RNA.

References

  1. Valadi, H. et al. Nat. Cell Biol. 9, 654–659 (2007).

    Article  CAS  Google Scholar 

  2. Baj-Krzyworzeka, M. et al. Cancer Immunol. Immunother. 55, 808–818 (2006).

    Article  CAS  Google Scholar 

  3. Leidal, A. M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0450-y (2020).

  4. Mattick, J. S. Nat. Rev. Genet. 5, 316–323 (2004).

    Article  CAS  Google Scholar 

  5. Das, S. et al. Cell 177, 231–242 (2019).

    Article  CAS  Google Scholar 

  6. Samuel, M., Bleackley, M., Anderson, M. & Mathivanan, S. Front. Plant Sci. 6, 766 (2015).

    Article  Google Scholar 

  7. Villarroya-Beltri, C. et al. Nat. Commun. 4, 2980 (2013).

    Article  Google Scholar 

  8. Abels, E. R. & Breakefield, X. O. Cell. Mol. Neurobiol. 36, 301–312 (2016).

    Article  CAS  Google Scholar 

  9. Ohsumi, Y. Cell Res. 24, 9–23 (2014).

    Article  CAS  Google Scholar 

  10. New, J. & Thomas, S. M. Autophagy 15, 1682–1693 (2019).

    Article  CAS  Google Scholar 

  11. Théry, C. et al. J. Extracell. Vesicles 7, 1535750 (2018).

    Article  Google Scholar 

  12. Trajkovic, K. et al. Science 319, 1244–1247 (2008).

    Article  CAS  Google Scholar 

  13. van Niel, G., D’Angelo, G. & Raposo, G. Nat. Rev. Mol. Cell Biol. 19, 213–228 (2018).

    Article  Google Scholar 

  14. Choi, D. et al. ACS Nano 13, 10499–10511 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. McGill University and the Research Institute of the McGill University Health Centre, Montreal, Canada

    Janusz Rak

Authors
  1. Janusz Rak
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Janusz Rak.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rak, J. L(C3)icensing of exosomes for RNA export. Nat Cell Biol 22, 137–139 (2020). https://doi.org/10.1038/s41556-020-0466-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-020-0466-3

  • Springer Nature Limited

This article is cited by

Search

Navigation