Components of the spliceosome are frequently mutated in haematopoietic malignancies. Identification of mis-spliced genes promoting transformation will uncover novel targeted therapies. Now, a long isoform of IRAK4 is shown to be upregulated in a subset of acute myeloid leukaemia patients, conferring susceptibility for IRAK4 inhibition therapy.
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Guillamot, M., Aifantis, I. Splicing the innate immune signalling in leukaemia. Nat Cell Biol 21, 536–537 (2019). https://doi.org/10.1038/s41556-019-0323-4
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DOI: https://doi.org/10.1038/s41556-019-0323-4
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