Healthy and malignant haematopoietic stem cells (HSCs) must overcome a variety of cell intrinsic and extrinsic stresses to maintain their functionality. Now, IRE1α –XBP1 signalling is shown to protect HSCs and to promote survival of, and confer competitive advantages to, NRAS-mutated pre-leukaemic cells.
References
Trumpp, A. et al. Nat. Rev. Immunol. 10, 201–209 (2010).
Corazzari, M. et al. Front. Oncol. 7, 00078 (2017).
Sano, R. & Reed, J. C. Biochim. Biophys. Acta. 1833, 3460–3470 (2013).
Hetz, C. & Papa F. R. Mol Cell. 69, 169–181 (2018).
Sigurdsson, V. & Miharada, K. Int. J. Hematol. 107, 627–633 (2018).
Liu, L. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0285-6 (2019).
van Galen, P. et al. Nature 510, 268–272 (2014).
Chapple, R. H. et al. eLife 7, e31159 (2018).
Iwawaki, T. et al. Nat. Med. 10, 98–102 (2004).
Signer, R. A. et al. Nature 509, 49–54 (2014).
Miharada, K. et al. Cell Rep. 7, 1381–1392 (2014).
Jin, X. et al. Blood Adv. 2, 1259–1271 (2018).
Bowman, R. L. et al. Cell Stem Cell 22, 157–170 (2018).
Ward, A. F. et al. Blood 120, 3397–3406 (2012).
Jiang, D. et al. Semin. Cancer Biol. 33, 48–56 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
C. Müller-Tidow's leukaemia research in Investigator Initiated Trials is supported by Pfizer, Janssen and Daiichi Sankyo. Clinical trials and other research within the Department of Medicine, Hematology, Oncology and Rheumatology are supported by multiple pharmaceutical companies.
Rights and permissions
About this article
Cite this article
Scheller-Wendorff, M., Müller-Tidow, C. IRE1α maintains HSC stemness under ER-stress. Nat Cell Biol 21, 297–298 (2019). https://doi.org/10.1038/s41556-019-0295-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-019-0295-4
- Springer Nature Limited