Cell metabolism ensures that cell dynamics and continued renewal are supported by a constant flow of matter that consumes energy. A new study shows that cell metabolism is sensitive to mechanical cues, revealing that the level of cell contraction modulates the production and storage of lipids, which could serve as fuel for energy production.
This is a preview of subscription content, log in via an institution to check access.
References
Ivanovska, I. L., Shin, J.-W., Swift, J. & Discher, D. E. Trends Cell Biol. 25, 523–532 (2015).
Streichan, S. J., Hoerner, C. R., Schneidt, T., Holzer, D. & Hufnagel, L. Proc. Natl Acad. Sci. USA 111, 5586–5591 (2014).
McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K. & Chen, C. S. Dev. Cell 6, 483–495 (2004).
Palm, W. & Thompson, C. B. Nature 546, 234–242 (2017).
Ata, R. & Antonescu, C. N. Int. J. Mol. Sci. 18, (2017).
Bays, J. L., Campbell, H. K., Heidema, C., Sebbagh, M. & DeMali, K. A. Nat. Cell Biol. 19, 724–731 (2017).
Romani, P. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0270-5 (2019).
Kim, J. Y. et al. Cell 175, 133–145 (2018).
Walker, A. K. et al. Cell 147, 840–852 (2011).
Schiller, H. B. et al. Nat. Cell Biol. 15, 625–636 (2013).
Mendez, M. G. & Janmey, P. A. Int. J. Biochem. Cell Biol. 44, 728–732 (2012).
Peterson, T. R. et al. Cell 146, 408–420 (2011).
Han, H. et al. R Mol. Cell 72, 328–340e8 (2018).
Meng, Z. et al. Nature 560, 655–660 (2018).
Guet, D. et al. Curr. Biol. 24, 1700–1711 (2014).
Rashid, T. et al. EMBO J. 38, e99576 (2018).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Théry, M., Pende, M. Golgi mechanics controls lipid metabolism. Nat Cell Biol 21, 301–302 (2019). https://doi.org/10.1038/s41556-019-0289-2
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-019-0289-2
- Springer Nature Limited