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Epithelial polarity limits EMT

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Epithelial–mesenchymal transition (EMT) is crucial for development, and for dissemination and invasion of cancer cells. A study now identifies the apical–basolateral polarity status of epithelia as a checkpoint for EMT induction and tumour metastasis through aPKC–Par3-regulated degradation of the EMT transcription factor SNAI1.

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Fig. 1: Epithelial architecture status as a checkpoint for EMT.

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Authors and Affiliations

  1. Department of Dermatology, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany

    Oana-Diana Persa & Carien M. Niessen

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  1. Oana-Diana Persa
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  2. Carien M. Niessen
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Correspondence to Carien M. Niessen.

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The authors declare no competing interests.

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Persa, OD., Niessen, C.M. Epithelial polarity limits EMT. Nat Cell Biol 21, 299–300 (2019). https://doi.org/10.1038/s41556-019-0284-7

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