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CELL CYCLE

CENP-T bears the load in mitosis

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During mitosis, the kinetochore connects chromosomes to spindle microtubules and enables chromosome segregation. A genetic study in vertebrate cells demonstrates phosphorylation-regulated plasticity of kinetochore assembly and highlights the role of the centromere protein T in load-bearing kinetochore–microtubule attachment.

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Fig. 1: Phosphorylation-regulated kinetochore plasticity during mitosis.

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Authors and Affiliations

  1. Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Yang Yang & Hongtao Yu

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  1. Yang Yang
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  2. Hongtao Yu
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Correspondence to Hongtao Yu.

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Yang, Y., Yu, H. CENP-T bears the load in mitosis. Nat Cell Biol 20, 1335–1337 (2018). https://doi.org/10.1038/s41556-018-0241-x

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