Metastatic colonization of distant organs is the prime cause of mortality from cancer, and is governed by a series of steps that include survival and growth in the perivascular niche. A study now shows that L1CAM is necessary for tight physical interactions in this niche, involving a YAP–MRTF–β1-integrin mechanotransduction pathway.
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Karreman, M.A., Winkler, F. The mechanics of metastatic seeding. Nat Cell Biol 20, 860–862 (2018). https://doi.org/10.1038/s41556-018-0162-8
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DOI: https://doi.org/10.1038/s41556-018-0162-8
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