Specific combinations of mutations cause unique signalling and metabolic requirements. Concurrent G-protein αs (GNAS) and KRAS mutations in a subset of pancreatic tumours are now shown to inhibit SIK kinases through aberrant cAMP–PKA activation, triggering a metabolic program defined by lipid metabolism and fatty acid oxidation.
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Hollstein, P.E., Shaw, R.J. GNAS shifts metabolism in pancreatic cancer. Nat Cell Biol 20, 740–741 (2018). https://doi.org/10.1038/s41556-018-0120-5
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DOI: https://doi.org/10.1038/s41556-018-0120-5
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