During mouse back skin development, subsets of fibroblastic lineages transition from anti-fibrotic Engrailed-1 (En1) negative to pro-fibrotic En1-positive cells. Injuries of adult skin heal with scarring, whereas En1-deficient embryonic fibroblasts have the potential to promote scarless regeneration and repair.
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Yokoyama, M., Rafii, S. Setting up the dermis for scar-free healing. Nat Cell Biol 20, 365–366 (2018). https://doi.org/10.1038/s41556-018-0080-9
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DOI: https://doi.org/10.1038/s41556-018-0080-9
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