Intrinsic factors that regulate dormancy of disseminated tumour cells (DTCs) are predominantly unknown. Now, knockdown of MSK1 is shown to accelerate bone metastasis of luminal breast cancer cells. MSK1 acts through epigenetic mechanisms that enforce the luminal phenotype and promote steady-state maintenance of DTCs within bone.
References
Uhr, J. W. & Pantel, K. Proc. Natl Acad. Sci. USA 108, 12396–12400 (2011).
Ghajar, C. M. et al. Nat. Cell. Biol. 15, 807–817 (2013).
Folkman, J. N. Engl. J. Med. 285, 1182–1186 (1971).
Gimbrone, M. A. Jr., Leapman, S. B., Cotran, R. S. & Folkman, J. J. Exp. Med. 136, 261–276 (1972).
Koebel, C. M. et al. Nature 450, 903–907 (2007).
Muller-Hermelink, N. et al. Cancer Cell. 13, 507–518 (2008).
Gawrzak, S. R. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-017-0021-z (2018).
Copson, E. et al. J. Natl Cancer I. 105, 978–988 (2013).
Perou, C. M. et al. Nature 406, 747–752 (2000).
Haque, R. et al. Cancer Epidem. Biomar. 21, 1848–1855 (2012).
Aguirre-Ghiso, J. A., Liu, D., Mignatti, A., Kovalski, K. & Ossowski, L. Mol. Biol. Cell. 12, 863–879 (2001).
Dontu, G. et al. Genes. Dev. 17, 1253–1270 (2003).
Lacroix, M. & Leclercq, G. Mol. Cell. Endocrinol. 219, 1–7 (2004).
Brami-Cherrier, K., Roze, E., Girault, J. A., Betuing, S. & Caboche, J. J. Neurochem. 108, 1323–1335 (2009).
Kennecke, H. et al. J. Clin. Oncol. 28, 3271–3277 (2010).
Rakhra, K. et al. Cancer Cell 18, 485–498 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Grzelak, C.A., Ghajar, C.M. Illuminating MSK1’s role in tumour dormancy. Nat Cell Biol 20, 124–126 (2018). https://doi.org/10.1038/s41556-018-0035-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-018-0035-1
- Springer Nature Limited