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Sugar fuels T-cell memory

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Previous work has highlighted the role of metabolic shifts in regulating the formation of memory T cells, which are generated during a primary infection to provide long-lasting immunity. A study now shows that memory T cells rely on a gluconeogenesis–glycogenolysis cycle to provide antioxidant defence and support their survival.

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Fig. 1: The role of glycogen metabolism in the formation and maintenance of memory T cells.

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Authors and Affiliations

  1. Department of Genetics & Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA

    Joanna Olivas & Tiffany Horng

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  1. Joanna Olivas
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  2. Tiffany Horng
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Correspondence to Tiffany Horng.

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The authors declare no competing financial interests.

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Olivas, J., Horng, T. Sugar fuels T-cell memory. Nat Cell Biol 20, 2–3 (2018). https://doi.org/10.1038/s41556-017-0014-y

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