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Targeting the PIEZO1 pathway boosts T cell antitumour cytotoxicity

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The mechanical sensor PIEZO1 regulates the traction force that is critical for cytotoxic T cells to target tumour cells. This finding creates avenues for enhancing the efficacy of T cell-targeted immune therapies.

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Fig. 1: The PIEZO1–GRHL3–RNF114–F-actin pathway regulates T cell cytotoxicity.

References

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This is a summary of: Pang, R. et al. PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-024-01188-5 (2024).

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Targeting the PIEZO1 pathway boosts T cell antitumour cytotoxicity. Nat. Biomed. Eng (2024). https://doi.org/10.1038/s41551-024-01189-4

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  • DOI: https://doi.org/10.1038/s41551-024-01189-4

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