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Screening for drivers of SARS-CoV-2 uptake

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Genetic and cellular drivers of the cellular uptake of SARS-CoV-2 can be screened at high throughput via droplet microfluidics and size-exclusion methods for the analysis of the formation of fusions between cells expressing the virus’s spike protein and cells expressing the protein’s receptor.

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Fig. 1: High-throughput screening of drivers of syncytium formation between cells expressing the spike protein of SARS-CoV-2 and cells expressing the ACE2 receptor.

References

  1. V’kovski, P., Kratzel, A., Steiner, S., Stalder, H. & Thiel, V. Nat. Rev. Microbiol. 19, 155–170 (2021).

    Article  PubMed  Google Scholar 

  2. Braga, L. et al. Nature 594, 88–93 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Sanders, D. W. et al. eLife 10, e65962 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Francino-Urdaniz, I. M. et al. Cell Rep. 36, 109627 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Merten, C. A. et al. J. Virol. 79, 834–840 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Chan, C. W. F. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-023-01140-z (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Gérard, A. et al. Nat. Biotechnol. 38, 715–721 (2020).

    Article  PubMed  Google Scholar 

  8. El Debs, B., Utharala, R., Balyasnikova, I. V., Griffiths, A. D. & Merten, C. A. Proc. Natl Acad. Sci. USA 109, 11570–11575 (2012).

    Article  CAS  PubMed  Google Scholar 

  9. Eduati, F. et al. Nat. Commun. 9, 2434 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Christoph A. Merten.

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Autour, A., Merten, C.A. Screening for drivers of SARS-CoV-2 uptake. Nat. Biomed. Eng 8, 205–206 (2024). https://doi.org/10.1038/s41551-023-01170-7

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