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Computational medicine

Designing stable humanized antibodies

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Humanized versions of antibodies with enhanced stability can be designed via the systematic energy-based ranking of computationally grafted non-human complementarity-determining regions onto thousands of human frameworks.

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Fig. 1: Methods for antibody humanization.

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Authors and Affiliations

  1. Department of Statistics, University of Oxford, Oxford, UK

    Alissa M. Hummer & Charlotte M. Deane

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  1. Alissa M. Hummer
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  2. Charlotte M. Deane
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Correspondence to Charlotte M. Deane.

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The authors declare no competing interests.

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Hummer, A.M., Deane, C.M. Designing stable humanized antibodies. Nat. Biomed. Eng 8, 3–4 (2024). https://doi.org/10.1038/s41551-023-01168-1

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