Cellular encapsulation holds promise for immunosuppression-free pancreatic islet transplantation. However, long-term graft survival remains a challenge, especially at the subcutaneous site. We harnessed temporary, controlled, inflammation-induced neovascularization to create a modified subcutaneous cavity that supports long-term survival and function of a customized islet encapsulation device without immunosuppression.
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This is a summary of: Wang, L.-H. et al. Inflammation-induced subcutaneous neovascularization for the long-term survival of encapsulated islets without immunosuppression. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-023-01145-8 (2023).
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Subcutaneous pancreatic islet transplantation without immunosuppression. Nat. Biomed. Eng (2023). https://doi.org/10.1038/s41551-023-01158-3
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DOI: https://doi.org/10.1038/s41551-023-01158-3
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