Skip to main content
SpringerLink
Log in

Lab-on-a-chip devices

Rapid deformability cytometry for tissue biopsies

  • News & Views
  • Published:

From Nature Biomedical Engineering

View current issue Submit your manuscript

The physical phenotypes of malignant cells in tissue biopsies can be rapidly characterized at high throughput via deformability cytometry after singularizing the cells into a suspension by using a tissue grinder.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Workflow for real-time fluorescence deformability cytometry, from tissue dissociation to sample classification.

References

  1. Di Carlo, D. J. Lab Autom. 17, 32–42 (2012).

    Article  PubMed  Google Scholar 

  2. Costa, K. Dis. Markers 19, 139–154 (2003).

    Article  PubMed  Google Scholar 

  3. Urbanska, M. et al. Nat. Methods 17, 587–593 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Guillou, L. et al. PLoS ONE 16, e0246980 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Soteriou, D. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-023-01015-3 (2023).

    Article  PubMed  Google Scholar 

  6. Rivenson, Y. et al. Nat. Biomed. Eng. 3, 466–477 (2019).

    Article  CAS  PubMed  Google Scholar 

  7. Nawaz, A. et al. Nat. Methods 17, 595–599 (2020).

    Article  CAS  PubMed  Google Scholar 

  8. Liu, Y. et al. Sci. Immunol. 7, eabl9165 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Bioengineering and Mechanical & Aerospace Engineering, University of California Los Angeles, Los Angeles, CA, USA

    Dino Di Carlo

Authors
  1. Dino Di Carlo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dino Di Carlo.

Ethics declarations

Competing interests

D.D.C. and the Regents of the University of California have financial interests in Cytovale Inc., which is commercializing deformability cytometry technology.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Di Carlo, D. Rapid deformability cytometry for tissue biopsies. Nat. Biomed. Eng 7, 1337–1339 (2023). https://doi.org/10.1038/s41551-023-01110-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-023-01110-5

  • Springer Nature Limited

Search

Navigation