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Phagocytic cooperativity by tumour macrophages

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Disrupting the CD47–SIRPα checkpoint in tumour macrophages and delivering a tumour-opsonizing monoclonal antibody maximizes the macrophages’ cooperative phagocytic potency.

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Fig. 1: Combining CD47 blockade with tumour-opsonizing antibodies leads to macrophage activation and to the disruption of spatial organization in the tumour.

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Authors and Affiliations

  1. Whitehead Institute for Biomedical Research, Cambridge, MA, USA

    Asaf Maoz & Kipp Weiskopf

  2. Dana-Farber Cancer Institute, Boston, MA, USA

    Asaf Maoz & Kipp Weiskopf

Authors
  1. Asaf Maoz
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  2. Kipp Weiskopf
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Corresponding author

Correspondence to Kipp Weiskopf.

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Competing interests

A.M. and K.W. have filed US patent applications related to macrophage-based cancer therapies via the Whitehead Institute. K.W. holds relevant patents and royalties (via Stanford University, the Whitehead Institute and Gilead Sciences), is a co-founder, scientific advisory board member and equity holder of ALX Oncology, DEM Biopharma and Solu Therapeutics, has been a scientific advisor of Carisma Therapeutics and owns stock of Ginkgo Bioworks.

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Maoz, A., Weiskopf, K. Phagocytic cooperativity by tumour macrophages. Nat. Biomed. Eng 7, 1057–1059 (2023). https://doi.org/10.1038/s41551-023-01088-0

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