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A hydrogel-entrapped live virus immunization

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Confining the Zika virus within a self-adjuvanting hydrogel that forms a subcutaneous inflammatory niche stimulates strong immune responses in mice without inducing infection.

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Fig. 1: An entrapped live Zika virus as a vaccine.

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Authors and Affiliations

  1. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA

    Ningqiang Gong, Alex G. Hamilton & Michael J. Mitchell

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  1. Ningqiang Gong
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  2. Alex G. Hamilton
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  3. Michael J. Mitchell
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Correspondence to Michael J. Mitchell.

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The authors declare no competing interests.

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Gong, N., Hamilton, A.G. & Mitchell, M.J. A hydrogel-entrapped live virus immunization. Nat. Biomed. Eng 7, 849–850 (2023). https://doi.org/10.1038/s41551-023-01008-2

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