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CANCER IMMUNOTHERAPY

Arming T cells to infiltrate pancreatic tumours

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The efficacy of adoptive cell therapy for pancreatic cancer can be augmented by antigen-specific cytotoxic T cells genetically engineered to overexpress a C-X-C chemokine receptor whose ligand is highly expressed by pancreatic cancer cells.

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Fig. 1: Adoptively transferred T cells engineered to overexpress CXCR6 infiltrate and accumulate in the vasculature of pancreatic tumours.

References

  1. June, C. H. & Sadelain, M. N. Engl. J. Med. 379, 64–73 (2018).

    Article  CAS  Google Scholar 

  2. Grupp, S. A. et al. N. Engl. J. Med. 368, 1509–1518 (2013).

    Article  CAS  Google Scholar 

  3. Brentjens, R. J. et al. Sci. Transl. Med. 5, 177ra38 (2013).

    Article  Google Scholar 

  4. Grosser, R., Cherkassky, L., Chintala, N. & Adusumilli, P. S. Cancer Cell 36, 471–482 (2019).

    Article  CAS  Google Scholar 

  5. Lesch, S. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-021-00737-6 (2021).

    Article  PubMed  Google Scholar 

  6. Davenport, A. J. et al. Cancer Immunol. Res. 3, 483–494 (2015).

    Article  CAS  Google Scholar 

  7. Morello, A., Sadelain, M. & Adusumilli, P. S. Cancer Discov. 6, 133–146 (2016).

    Article  CAS  Google Scholar 

  8. Beatty, G. L. et al. Gastroenterology 155, 29–32 (2018).

    Article  CAS  Google Scholar 

  9. Pastan, I. & Hassan, R. Cancer Res. 74, 2907–2912 (2014).

    Article  CAS  Google Scholar 

  10. Kachala, S. S. et al. Clin. Cancer Res. 20, 1020–1028 (2014); erratum 20, 3896 (2014).

  11. Servais, E. L. et al. Clin. Cancer Res. 18, 2478–2489 (2012).

    Article  CAS  Google Scholar 

  12. Cherkassky, L. et al. J. Clin. Invest. 126, 3130–3144 (2016).

    Article  Google Scholar 

  13. Adusumilli, P. S. et al. Sci. Transl. Med. 6, 261ra151 (2014).

    Article  Google Scholar 

  14. Adusumilli, P. S. et al. Cancer Discov. https://doi.org/10.1158/2159-8290.CD-21-0407 (2021).

    Article  PubMed  Google Scholar 

  15. Brown, C. E. et al. N. Engl. J. Med. 375, 2561–2569 (2016).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA

    Leonid Cherkassky

  2. Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA

    Leonid Cherkassky

  3. Thoracic Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Prasad S. Adusumilli

  4. Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Prasad S. Adusumilli

Authors
  1. Leonid Cherkassky
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  2. Prasad S. Adusumilli
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Corresponding author

Correspondence to Prasad S. Adusumilli.

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Competing interests

P.S.A. has received research funding from ATARA Biotherapeutics and Acea Biosciences; has served on the scientific advisory boards of, or as a consultant for, ATARA Biotherapeutics, Bayer, Carisma Therapeutics, Imugene, ImmpactBio and Takeda Therapeutics; has pending patent applications on T-cell therapies; and has patents, royalties and intellectual property on mesothelin-targeted CARs and other T-cell therapies and on methods for the detection of cancer cells using viruses. L.C. declares no competing interests.

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Cherkassky, L., Adusumilli, P.S. Arming T cells to infiltrate pancreatic tumours. Nat Biomed Eng 5, 1243–1245 (2021). https://doi.org/10.1038/s41551-021-00821-x

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