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CANCER IMMUNOTHERAPY

Modelling treatment-response rates

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The time course of tumour responses to immunotherapies can be mathematically predicted on the basis of tumour-growth rates, the rates of immune activation and of tumour–immune-cell interactions, and the efficacy of immune-mediated tumour killing.

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Fig. 1: A general mathematical model can discriminate patients who respond to immunotherapies from those who do not.

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Authors and Affiliations

  1. Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Clemens Grassberger

  2. Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

    Wilfred Ngwa

Authors
  1. Clemens Grassberger
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  2. Wilfred Ngwa
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Corresponding author

Correspondence to Wilfred Ngwa.

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The authors declare no competing interests.

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Grassberger, C., Ngwa, W. Modelling treatment-response rates. Nat Biomed Eng 5, 295–296 (2021). https://doi.org/10.1038/s41551-021-00717-w

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