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‘Hit and run’ therapy averts macular degeneration

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Subretinal delivery of lentiviruses bearing Cas9 mRNA and a guide RNA targeting the Vegfa gene reduces the development of choroidal neovascularization in a mouse model of wet age-related macular degeneration.

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Fig. 1: Lentiviral delivery of Cas9 mRNA and a Vegfa-targeting gRNA to retinal epithelium largely prevents the development of wet age-related macular degeneration in mice.

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Authors and Affiliations

  1. Department of Infectious Diseases/Virology, Medical Faculty, University of Heidelberg, Heidelberg, Germany

    Felix Bubeck & Dirk Grimm

  2. BioQuant, University of Heidelberg, Heidelberg, Germany

    Felix Bubeck & Dirk Grimm

  3. German Center for Infection Research (DZIF) and German Center for Cardiovascular Research (DZHK), Heidelberg, Germany

    Dirk Grimm

Authors
  1. Felix Bubeck
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  2. Dirk Grimm
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Correspondence to Dirk Grimm.

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Competing interests

D.G. is a co-founder and shareholder of AaviGen GmbH. F.B. and D.G. have filed patent applications related to CRISPR technologies and gene delivery via adeno-associated viruses.

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Bubeck, F., Grimm, D. ‘Hit and run’ therapy averts macular degeneration. Nat Biomed Eng 5, 132–133 (2021). https://doi.org/10.1038/s41551-021-00690-4

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