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IMPLANTED BIOMATERIALS

Long-term viability through selective permeability

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The cell-selective permeability of a retrievable microporous device encapsulating human therapeutic cells and implanted in the intraperitoneal space of mice provides long-term protection to the transplanted cells by dampening foreign-body responses and preventing the immune rejection of the graft.

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Fig. 1: A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells.

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Author information

Authors and Affiliations

  1. Project and Alliance Management, Novo Nordisk A/S, Måløv, Denmark

    Ken Coppieters

  2. Stem Cell Delivery & Pharmacology, Novo Nordisk A/S, Måløv, Denmark

    Louise Winkel

  3. Chief Medical Office, Novo Nordisk A/S, Søborg, Denmark

    Matthias von Herrath

  4. Type 1 Diabetes Center, The La Jolla Institute for Immunology, La Jolla, CA, USA

    Matthias von Herrath

Authors
  1. Ken Coppieters
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  2. Louise Winkel
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  3. Matthias von Herrath
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Corresponding author

Correspondence to Matthias von Herrath.

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Competing interests

All authors are employed by Novo Nordisk, hold shares in the company and are involved in the company’s stem cell research and development.

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Coppieters, K., Winkel, L. & von Herrath, M. Long-term viability through selective permeability. Nat Biomed Eng 4, 763–764 (2020). https://doi.org/10.1038/s41551-020-0602-1

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