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Detecting liver disease via an endogenous pigment

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Lipofuscin, an endogenous pigment, can be used as a near-infrared fluorescent biomarker to stage and to monitor the progression of chronic liver disease, as shown in mice with induced liver disease and in human livers biopsied from patients with liver fibrosis.

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Fig. 1: Detection and monitoring of liver pathologies via the endogenous pigment lipofuscin.

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Authors and Affiliations

  1. Department of Chemistry, University of California at Davis, Davis, CA, USA

    Justin J. O’Sullivan, Nathaniel H. O. Harder & Marie C. Heffern

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  1. Justin J. O’Sullivan
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  2. Nathaniel H. O. Harder
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  3. Marie C. Heffern
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Correspondence to Marie C. Heffern.

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O’Sullivan, J.J., Harder, N.H.O. & Heffern, M.C. Detecting liver disease via an endogenous pigment. Nat Biomed Eng 4, 761–762 (2020). https://doi.org/10.1038/s41551-020-0601-2

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