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An optimized antigen–protein fusion

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The fusion of an immunogenic peptide and the protein transthyretin protects the peptide antigen from proteolytic degradation, optimizes its uptake in local draining lymphatics and reduces its presentation in uninflamed distal lymphoid organs, as shown in mice.

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Fig. 1: Optimized antigen–protein fusion for efficient vaccination.

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Authors and Affiliations

  1. Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

    Pedro Romero & Alena Donda

  2. Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA

    Jeffrey A. Hubbell

Authors
  1. Pedro Romero
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  2. Alena Donda
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  3. Jeffrey A. Hubbell
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Corresponding author

Correspondence to Pedro Romero.

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Competing interests

P.R. is a member of the scientific advisory board of immatics biotechnologies GmbH. J.A.H. is co-founder of Arrow Immune, Inc., and through his university holds patents in immuno-oncology. The remaining author declares no competing interests.

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Romero, P., Donda, A. & Hubbell, J.A. An optimized antigen–protein fusion. Nat Biomed Eng 4, 583–584 (2020). https://doi.org/10.1038/s41551-020-0572-3

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