Structural and functional changes following infarction in a human heart can be modelled with human cardiac organoids set in a hypoxic gradient and stimulated with the neurotransmitter noradrenaline.
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R.M. and J.H. have collaborated with AstraZeneca for the discovery of new heart-failure drugs, are on the scientific advisory board of Dynomics for the discovery of new heart-failure drugs, and have patents related to bioengineered-tissue technologies and culture conditions, and to putative therapeutic targets for heart failure.
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Mills, R., Hudson, J. An in vitro model of myocardial infarction. Nat Biomed Eng 4, 366–367 (2020). https://doi.org/10.1038/s41551-020-0550-9
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DOI: https://doi.org/10.1038/s41551-020-0550-9
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