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DRUG DELIVERY

A topical gel for extended ocular drug release

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The delivery of drugs to the eye can be prolonged via a gelling hypotonic solution that forms a clear thin layer on the eye’s surface.

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Fig. 1: Optical coherence tomography images of the ocular surface of anaesthetized rats following topical application of liquid formulations of the thermogelling polymer F127, and then after manually triggered blinking.

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Authors and Affiliations

  1. Department of Ophthalmology, National University Hospital, Singapore, Singapore

    Ivan Seah & Xinyi Su

  2. Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

    Xian Jun Loh

  3. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Xinyi Su

  4. Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

    Xinyi Su

  5. Singapore Eye Research Institute (SERI), Singapore, Singapore

    Xinyi Su

Authors
  1. Ivan Seah
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  2. Xian Jun Loh
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  3. Xinyi Su
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Corresponding author

Correspondence to Xinyi Su.

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The authors declare no competing interests.

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Seah, I., Loh, X.J. & Su, X. A topical gel for extended ocular drug release. Nat Biomed Eng 4, 1024–1025 (2020). https://doi.org/10.1038/s41551-020-00645-1

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  • DOI: https://doi.org/10.1038/s41551-020-00645-1

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