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Homeostasis disrupted by strain mechanosensing

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In injured intervertebral discs, disruptions in fibre organization and in cellular contractility result in a fibrotic phenotype and progressive tissue degeneration.

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Fig. 1: Fibre pre-strain regulates homeostasis and maintenance of the viability, phenotype and morphology of cells in the intervertebral disc’s annulus fibrosus.

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Authors and Affiliations

  1. Leni & Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Tyler J. DiStefano & James C. Iatridis

  2. Emory University School of Medicine, Atlanta, GA, USA

    Svenja Illien-Jünger

Authors
  1. Tyler J. DiStefano
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  2. Svenja Illien-Jünger
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  3. James C. Iatridis
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Correspondence to James C. Iatridis.

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DiStefano, T.J., Illien-Jünger, S. & Iatridis, J.C. Homeostasis disrupted by strain mechanosensing. Nat Biomed Eng 3, 951–952 (2019). https://doi.org/10.1038/s41551-019-0491-3

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