Skip to main content

Advertisement

SpringerLink
Log in

CELL THERAPIES

Universally non-immunogenic iPSCs

  • News & Views
  • Published:

From Nature Biomedical Engineering

View current issue Submit your manuscript

Inactivation of the major histocompatibility complex and overexpression of the transmembrane protein CD47 renders induced pluripotent stem cells invisible to the immune system of the host.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Engineered hypoimmunogenic iPSCs via MHC class-I/II knockout and CD47 overexpression.

References

  1. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  2. Nakatsuji, N., Nakajima, F. & Tokunaga, K. Nat. Biotechnol. 26, 739–740 (2008).

    Article  CAS  Google Scholar 

  3. Deuse. et al. Nat. Biotechnol. 37, 252–258 (2019).

    Article  Google Scholar 

  4. Vento-Tormo, R. et al. Nature 563, 347–353 (2018).

    Article  CAS  Google Scholar 

  5. Majeti, R. et al. Cell 138, 286–299 (2009).

    Article  CAS  Google Scholar 

  6. Gamliel, M. et al. Immunity 48, 951–962 (2018).

    Article  CAS  Google Scholar 

  7. Hanna, J. et al. Science 318, 1920–1923 (2007).

    Article  CAS  Google Scholar 

  8. Soldner, F. & Jaenisch, R. Cell 175, 615–632 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

    Tom Shani & Jacob H. Hanna

Authors
  1. Tom Shani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jacob H. Hanna
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jacob H. Hanna.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shani, T., Hanna, J.H. Universally non-immunogenic iPSCs. Nat Biomed Eng 3, 337–338 (2019). https://doi.org/10.1038/s41551-019-0401-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-019-0401-8

  • Springer Nature Limited

This article is cited by

Search

Navigation