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Urinary nanosensors of early transplant rejection

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Nanoparticle sensors of the activity of the protease granzyme B detect early T-cell-mediated rejection of transplanted skin grafts in mice via the release of a proteolytically cleaved fluorescence reporter that filters into urine.

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Fig. 1: Nanosensors for detecting acute T-cell-mediated transplant rejection.

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Authors and Affiliations

  1. Section of Transplantation, Department of Surgery, The University of Chicago, Chicago, IL, USA

    Anita S. Chong

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  1. Anita S. Chong
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Correspondence to Anita S. Chong.

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Chong, A.S. Urinary nanosensors of early transplant rejection. Nat Biomed Eng 3, 251–252 (2019). https://doi.org/10.1038/s41551-019-0389-0

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