Skip to main content
Log in

CANCER IMMUNOTHERAPY

Tumour suppression by blocking palmitoylation

  • News & Views
  • Published:

From Nature Biomedical Engineering

View current issue Submit your manuscript

Enhanced lysosomal degradation of the transmembrane protein programmed cell-death protein-1 ligand in tumour cells, enabled by blocking the protein’s post-translational lipid modification, promotes T-cell-mediated suppression of tumour growth in mice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: Palmitoylation of PD-L1 and its suppression.

References

  1. Salmaninejad, A. et al. J. Cell Physiol. https://doi.org/10.1002/jcp.28358 (2019).

    Article  PubMed  Google Scholar 

  2. Wang, Y. et al. Front. Pharmacol. 9, 536 (2018).

    Article  Google Scholar 

  3. Peng, Y., Tang, F. & Weisman, L. S. Traffic 7, 1378–1387 (2006).

    Article  CAS  Google Scholar 

  4. Larkin, J., Hodi, F. S. & Wolchok, J. D. N. Engl. J. Med. 373, 1270–1271 (2015).

    Article  Google Scholar 

  5. Sharpe, A. H. & Pauken, K. E. Nat. Rev. Immunol. 18, 153–167 (2018).

    Article  CAS  Google Scholar 

  6. Linder, M. E. & Deschenes, R. J. Nat. Rev. Mol. Cell Biol. 8, 74–84 (2007).

    Article  CAS  Google Scholar 

  7. Yao, H. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-019-0375-6 (2019).

    Article  Google Scholar 

  8. Fukata, Y., Iwanaga, T. & Fukata, M. Methods 40, 177–182 (2006).

    Article  CAS  Google Scholar 

  9. Horita, H., Law, A., Hong, S. & Middleton, K. Neoplasia 19, 346–353 (2017).

    Article  CAS  Google Scholar 

  10. Hurley, J. H. & Emr, S. D. Annu. Rev. Biophys. Biomol. Struct. 35, 277–298 (2006).

    Article  CAS  Google Scholar 

  11. Valdez-Taubas, J. & Pelham, H. Embo. J. 24, 2524–2532 (2005).

    Article  CAS  Google Scholar 

  12. Dumaresq-Doiron, K., Jules, F. & Lefrancois, S. Biochem. Biophys. Res. Commun. 433, 90–95 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Stephane Lefrancois.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lefrancois, S. Tumour suppression by blocking palmitoylation. Nat Biomed Eng 3, 255–256 (2019). https://doi.org/10.1038/s41551-019-0383-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-019-0383-6

  • Springer Nature Limited

This article is cited by

Navigation